A hetero-Diels-Alder approach to complex pyrones: an improved synthesis of the spongistatin AB spiroketal.
نویسندگان
چکیده
The conversion of a substituted dioxinone to a pyrone was used in an improved synthesis of the AB spiroketal subunit of the spongistatins. This transformation occurred via a hetero-Diels-Alder reaction of an acyl ketene with butyl vinyl ether. A double diastereoselective Mukaiyama aldol reaction is used to provide the hetero-Diels-Alder precursor.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 8 5 شماره
صفحات -
تاریخ انتشار 2006